منابع مشابه
Scribble dictates orderly stem cell fate
Cell polarity has a variety of biological roles, including morphogenesis during development, the maintenance of tissue integrity, and adult tissue regeneration. In epithelial cells, cell polarity is generally regulated by three evolutionarily conserved protein complexes: the apical PAR and Crumbs complexes and the basolateral Scribble (Scrib) complex. Thus, dysfunction of these polarity protein...
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Adult hippocampal neurogenesis has been implicated in cognitive and emotional processes, as well as in response to antidepressant treatment. However, little is known about how the adult stem cell lineage contributes to hippocampal structure and function and how this process is modulated by the animal's experience. Here we perform an indelible lineage analysis and report that neural stem cells c...
متن کاملAltered nanofeature size dictates stem cell differentiation.
The differentiation of stem cells can be modulated by physical factors such as the micro- and nano-topography of the extracellular matrix. One important goal in stem cell research is to understand the concept that directs differentiation into a specific cell lineage in the nanoscale environment. Here, we demonstrate that such paths exist by controlling only the micro- and nano-topography of pol...
متن کاملI-19: Surrogate Egg Shell Culture for The Analysis of Avian Stem Cell Fate
Background: The chick embryo is a classical model to study embryonic development. However, most researchers have not studied the effect of embryonic manipulation on chick hatchability. To determine the effect of egg orientation and type of sealing film on the hatchability of cultured embryos, and to determine the fate of adulte stem cells injected into the blastoderm. Materials and Methods: Win...
متن کاملStem cell leukemia protein directs hematopoietic stem cell fate.
Stem cell leukemia (SCL) protein has been shown to be an essential transcription factor during hematopoietic development in the embryo. In adult hematopoiesis, however, the role for SCL has remained largely unknown, whereas it is expressed in bone marrow hematopoietic stem cells (HSCs). In this study, we performed HSC transplantation and an in vitro HSC differentiation assay using retrovirally ...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2015
ISSN: 1949-2553
DOI: 10.18632/oncotarget.4923